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We used proton magnetic resonance spectroscopy to examine resonances representing metabolites containing N-acetyl(NA)groups(predominantly N- acetyl aspartate),choline,and creatine within a large left-hemispheric gray matter heterotopia(GMH)in a 35 year old man with corpus callosum agenesis.In contrast to normal brain tissues,including gray matter regions,heterotopic gray matter was characterized by relatively increased choline and creatine resonances and a normal NA signal.These data suggest increased cellular activity or persistent immature neuronal tissue in GMH relative to unaffected tissue. |
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